Pharmacological potential of Populus nigra extract as antioxidant, anti-inflammatory, cardiovascular and hepatoprotective agent.
Identifieur interne : 002558 ( Main/Exploration ); précédent : 002557; suivant : 002559Pharmacological potential of Populus nigra extract as antioxidant, anti-inflammatory, cardiovascular and hepatoprotective agent.
Auteurs : Nadjet Debbache-Benaida [Algérie] ; Dina Atmani-Kilani ; Valérie Barbara Schini-Keirth ; Nouredine Djebbli ; Djebbar AtmaniSource :
- Asian Pacific journal of tropical biomedicine [ 2221-1691 ] ; 2013.
Descripteurs français
- KwdFr :
- Agents cardiovasculaires (pharmacologie), Agents protecteurs (pharmacologie), Analyse de variance (MeSH), Animaux (MeSH), Anti-inflammatoires (pharmacologie), Carragénane (toxicité), Chlorure d'aluminium (MeSH), Chlorures (toxicité), Composés de l'aluminium (toxicité), Extraits de plantes (composition chimique), Extraits de plantes (pharmacologie), Femelle (MeSH), Flavonoïdes (analyse), Fleurs (composition chimique), Foie (anatomopathologie), Foie (effets des médicaments et des substances chimiques), Lésions hépatiques dues aux substances (anatomopathologie), Lésions hépatiques dues aux substances (traitement médicamenteux), Monoxyde d'azote (métabolisme), Mâle (MeSH), Nitric oxide synthase type III (métabolisme), Oedème (induit chimiquement), Oedème (physiopathologie), Oedème (traitement médicamenteux), Phénols (analyse), Populus (composition chimique), Souris (MeSH), Tanins (analyse).
- MESH :
- analyse : Flavonoïdes, Phénols, Tanins.
- anatomopathologie : Foie, Lésions hépatiques dues aux substances.
- composition chimique : Extraits de plantes, Fleurs, Populus.
- effets des médicaments et des substances chimiques : Foie.
- induit chimiquement : Oedème.
- métabolisme : Monoxyde d'azote, Nitric oxide synthase type III.
- pharmacologie : Agents cardiovasculaires, Agents protecteurs, Anti-inflammatoires, Extraits de plantes.
- physiopathologie : Oedème.
- toxicité : Carragénane, Chlorures, Composés de l'aluminium.
- traitement médicamenteux : Lésions hépatiques dues aux substances, Oedème.
- Analyse de variance, Animaux, Chlorure d'aluminium, Femelle, Mâle, Souris.
English descriptors
- KwdEn :
- Aluminum Chloride (MeSH), Aluminum Compounds (toxicity), Analysis of Variance (MeSH), Animals (MeSH), Anti-Inflammatory Agents (pharmacology), Cardiovascular Agents (pharmacology), Carrageenan (toxicity), Chemical and Drug Induced Liver Injury (drug therapy), Chemical and Drug Induced Liver Injury (pathology), Chlorides (toxicity), Edema (chemically induced), Edema (drug therapy), Edema (physiopathology), Female (MeSH), Flavonoids (analysis), Flowers (chemistry), Liver (drug effects), Liver (pathology), Male (MeSH), Mice (MeSH), Nitric Oxide (metabolism), Nitric Oxide Synthase Type III (metabolism), Phenols (analysis), Plant Extracts (chemistry), Plant Extracts (pharmacology), Populus (chemistry), Protective Agents (pharmacology), Tannins (analysis).
- MESH :
- chemical , analysis : Flavonoids, Phenols, Tannins.
- chemical , chemistry : Plant Extracts.
- chemical , metabolism : Nitric Oxide, Nitric Oxide Synthase Type III.
- chemical , pharmacology : Anti-Inflammatory Agents, Cardiovascular Agents, Plant Extracts, Protective Agents.
- chemical , toxicity : Aluminum Compounds, Carrageenan, Chlorides.
- chemical : Aluminum Chloride.
- chemically induced : Edema.
- chemistry : Flowers, Populus.
- drug effects : Liver.
- drug therapy : Chemical and Drug Induced Liver Injury, Edema.
- pathology : Chemical and Drug Induced Liver Injury, Liver.
- physiopathology : Edema.
- Analysis of Variance, Animals, Female, Male, Mice.
Abstract
OBJECTIVE
To evaluate antioxidant, anti-inflammatory, hepatoprotective and vasorelaxant activities of Populus nigra flower buds ethanolic extract.
METHODS
Antioxidant and anti-inflammatory activities of the extract were assessed using respectively the ABTS test and the animal model of carrageenan-induced paw edema. Protection from hepatic toxicity caused by aluminum was examined by histopathologic analysis of liver sections. Vasorelaxant effect was estimated in endothelium-intact and -rubbed rings of porcine coronary arteries precontracted with high concentration of U46619.
RESULTS
The results showed a moderate antioxidant activity (40%), but potent anti-inflammatory activity (49.9%) on carrageenan-induced mice paw edema, and also as revealed by histopathologic examination, complete protection against AlCl₃-induced hepatic toxicity. Relaxant effects of the same extract on vascular preparation from porcine aorta precontracted with high concentration of U46619 were considerable at 10⁻¹ g/L, and comparable (P>0.05) between endothelium-intact (67.74%, IC₅₀=0.04 mg/mL) and -rubbed (72.72%, IC₅₀=0.075 mg/mL) aortic rings.
CONCLUSIONS
The extract exerted significant anti-inflammatory, hepatoprotective and vasorelaxant activities, the latter being endothelium-independent believed to be mediated mainly by the ability of components present in the extract to exert antioxidant properties, probably related to an inhibition of Ca²⁺ influx.
DOI: 10.1016/S2221-1691(13)60141-0
PubMed: 23998009
PubMed Central: PMC3757277
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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(metabolism)</term><term>Phenols (analysis)</term><term>Plant Extracts (chemistry)</term><term>Plant Extracts (pharmacology)</term><term>Populus (chemistry)</term><term>Protective Agents (pharmacology)</term><term>Tannins (analysis)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agents cardiovasculaires (pharmacologie)</term><term>Agents protecteurs (pharmacologie)</term><term>Analyse de variance (MeSH)</term><term>Animaux (MeSH)</term><term>Anti-inflammatoires (pharmacologie)</term><term>Carragénane (toxicité)</term><term>Chlorure d'aluminium (MeSH)</term><term>Chlorures (toxicité)</term><term>Composés de l'aluminium (toxicité)</term><term>Extraits de plantes (composition chimique)</term><term>Extraits de plantes (pharmacologie)</term><term>Femelle (MeSH)</term><term>Flavonoïdes (analyse)</term><term>Fleurs (composition chimique)</term><term>Foie (anatomopathologie)</term><term>Foie (effets des médicaments et des substances chimiques)</term><term>Lésions hépatiques dues aux substances (anatomopathologie)</term><term>Lésions hépatiques dues aux substances (traitement médicamenteux)</term><term>Monoxyde d'azote (métabolisme)</term><term>Mâle (MeSH)</term><term>Nitric oxide synthase type III (métabolisme)</term><term>Oedème (induit chimiquement)</term><term>Oedème (physiopathologie)</term><term>Oedème (traitement médicamenteux)</term><term>Phénols (analyse)</term><term>Populus (composition chimique)</term><term>Souris (MeSH)</term><term>Tanins (analyse)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Flavonoids</term><term>Phenols</term><term>Tannins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Nitric Oxide</term><term>Nitric Oxide Synthase Type III</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Cardiovascular Agents</term><term>Plant Extracts</term><term>Protective Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Aluminum Compounds</term><term>Carrageenan</term><term>Chlorides</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Aluminum Chloride</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Flavonoïdes</term><term>Phénols</term><term>Tanins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Foie</term><term>Lésions hépatiques dues aux substances</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Edema</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Flowers</term><term>Populus</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Extraits de plantes</term><term>Fleurs</term><term>Populus</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Liver</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Chemical and Drug Induced Liver Injury</term><term>Edema</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Foie</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Oedème</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Monoxyde d'azote</term><term>Nitric oxide synthase type III</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Chemical and Drug Induced Liver Injury</term><term>Liver</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agents cardiovasculaires</term><term>Agents protecteurs</term><term>Anti-inflammatoires</term><term>Extraits de plantes</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Oedème</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Edema</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Carragénane</term><term>Chlorures</term><term>Composés de l'aluminium</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lésions hépatiques dues aux substances</term><term>Oedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Female</term><term>Male</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de variance</term><term>Animaux</term><term>Chlorure d'aluminium</term><term>Femelle</term><term>Mâle</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To evaluate antioxidant, anti-inflammatory, hepatoprotective and vasorelaxant activities of Populus nigra flower buds ethanolic extract.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Antioxidant and anti-inflammatory activities of the extract were assessed using respectively the ABTS test and the animal model of carrageenan-induced paw edema. Protection from hepatic toxicity caused by aluminum was examined by histopathologic analysis of liver sections. Vasorelaxant effect was estimated in endothelium-intact and -rubbed rings of porcine coronary arteries precontracted with high concentration of U46619.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The results showed a moderate antioxidant activity (40%), but potent anti-inflammatory activity (49.9%) on carrageenan-induced mice paw edema, and also as revealed by histopathologic examination, complete protection against AlCl₃-induced hepatic toxicity. Relaxant effects of the same extract on vascular preparation from porcine aorta precontracted with high concentration of U46619 were considerable at 10⁻¹ g/L, and comparable (P>0.05) between endothelium-intact (67.74%, IC₅₀=0.04 mg/mL) and -rubbed (72.72%, IC₅₀=0.075 mg/mL) aortic rings.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>The extract exerted significant anti-inflammatory, hepatoprotective and vasorelaxant activities, the latter being endothelium-independent believed to be mediated mainly by the ability of components present in the extract to exert antioxidant properties, probably related to an inhibition of Ca²⁺ influx.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23998009</PMID><DateCompleted><Year>2014</Year><Month>05</Month><Day>14</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">2221-1691</ISSN><JournalIssue CitedMedium="Internet"><Volume>3</Volume><Issue>9</Issue><PubDate><Year>2013</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Asian Pacific journal of tropical biomedicine</Title><ISOAbbreviation>Asian Pac J Trop Biomed</ISOAbbreviation></Journal><ArticleTitle>Pharmacological potential of Populus nigra extract as antioxidant, anti-inflammatory, cardiovascular and hepatoprotective agent.</ArticleTitle><Pagination><MedlinePgn>697-704</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/S2221-1691(13)60141-0</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To evaluate antioxidant, anti-inflammatory, hepatoprotective and vasorelaxant activities of Populus nigra flower buds ethanolic extract.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Antioxidant and anti-inflammatory activities of the extract were assessed using respectively the ABTS test and the animal model of carrageenan-induced paw edema. Protection from hepatic toxicity caused by aluminum was examined by histopathologic analysis of liver sections. Vasorelaxant effect was estimated in endothelium-intact and -rubbed rings of porcine coronary arteries precontracted with high concentration of U46619.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The results showed a moderate antioxidant activity (40%), but potent anti-inflammatory activity (49.9%) on carrageenan-induced mice paw edema, and also as revealed by histopathologic examination, complete protection against AlCl₃-induced hepatic toxicity. Relaxant effects of the same extract on vascular preparation from porcine aorta precontracted with high concentration of U46619 were considerable at 10⁻¹ g/L, and comparable (P>0.05) between endothelium-intact (67.74%, IC₅₀=0.04 mg/mL) and -rubbed (72.72%, IC₅₀=0.075 mg/mL) aortic rings.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The extract exerted significant anti-inflammatory, hepatoprotective and vasorelaxant activities, the latter being endothelium-independent believed to be mediated mainly by the ability of components present in the extract to exert antioxidant properties, probably related to an inhibition of Ca²⁺ influx.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Debbache-Benaida</LastName><ForeName>Nadjet</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Laboratory of Applied Biochemistry, Faculty of Nature and Life Sciences, University A. Mira, Bejaia, 06000 Algeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Atmani-Kilani</LastName><ForeName>Dina</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Schini-Keirth</LastName><ForeName>Valérie Barbara</ForeName><Initials>VB</Initials></Author><Author ValidYN="Y"><LastName>Djebbli</LastName><ForeName>Nouredine</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Atmani</LastName><ForeName>Djebbar</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Asian Pac J Trop Biomed</MedlineTA><NlmUniqueID>101557706</NlmUniqueID><ISSNLinking>2221-1691</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017607">Aluminum Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000893">Anti-Inflammatory Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002317">Cardiovascular Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002712">Chlorides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005419">Flavonoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010636">Phenols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020011">Protective Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013634">Tannins</NameOfSubstance></Chemical><Chemical><RegistryNumber>31C4KY9ESH</RegistryNumber><NameOfSubstance UI="D009569">Nitric Oxide</NameOfSubstance></Chemical><Chemical><RegistryNumber>3CYT62D3GA</RegistryNumber><NameOfSubstance UI="D000077410">Aluminum Chloride</NameOfSubstance></Chemical><Chemical><RegistryNumber>9000-07-1</RegistryNumber><NameOfSubstance UI="D002351">Carrageenan</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.13.39</RegistryNumber><NameOfSubstance UI="D052250">Nitric Oxide Synthase Type III</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.13.39</RegistryNumber><NameOfSubstance UI="C496315">Nos3 protein, mouse</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000077410" MajorTopicYN="N">Aluminum Chloride</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017607" MajorTopicYN="N">Aluminum Compounds</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000893" MajorTopicYN="N">Anti-Inflammatory Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002317" MajorTopicYN="N">Cardiovascular Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002351" MajorTopicYN="N">Carrageenan</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056486" MajorTopicYN="N">Chemical and Drug Induced Liver Injury</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002712" MajorTopicYN="N">Chlorides</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004487" MajorTopicYN="N">Edema</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005419" MajorTopicYN="N">Flavonoids</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D035264" MajorTopicYN="N">Flowers</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009569" MajorTopicYN="N">Nitric Oxide</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D052250" MajorTopicYN="N">Nitric Oxide Synthase Type III</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010636" MajorTopicYN="N">Phenols</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020011" MajorTopicYN="N">Protective Agents</DescriptorName><QualifierName UI="Q000494" 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PubStatus="pubmed"><Year>2013</Year><Month>9</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>5</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23998009</ArticleId><ArticleId IdType="doi">10.1016/S2221-1691(13)60141-0</ArticleId><ArticleId IdType="pii">apjtb-03-09-697</ArticleId><ArticleId IdType="pmc">PMC3757277</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Pflugers Arch. 2010 May;459(6):853-62</Citation><ArticleIdList><ArticleId IdType="pubmed">20224869</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Pharmacol. 2011 Nov;164(6):1684-97</Citation><ArticleIdList><ArticleId IdType="pubmed">21557738</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Clin Nutr. 2006 Feb;83(2):421S-426S</Citation><ArticleIdList><ArticleId IdType="pubmed">16470006</ArticleId></ArticleIdList></Reference><Reference><Citation>Food Chem Toxicol. 2010 Oct;48(10):3017-21</Citation><ArticleIdList><ArticleId IdType="pubmed">20691749</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Inflam. 2011;2011:514623</Citation><ArticleIdList><ArticleId IdType="pubmed">21860805</ArticleId></ArticleIdList></Reference><Reference><Citation>Circ Res. 2001 Nov 9;89(10):923-9</Citation><ArticleIdList><ArticleId IdType="pubmed">11701620</ArticleId></ArticleIdList></Reference><Reference><Citation>Atherosclerosis. 2007 Nov;195(1):e58-64</Citation><ArticleIdList><ArticleId IdType="pubmed">17399719</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Med Res Opin. 2010 Jul;26(7):1715-31</Citation><ArticleIdList><ArticleId IdType="pubmed">20470236</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1994 Oct 21;269(42):26066-75</Citation><ArticleIdList><ArticleId IdType="pubmed">7929318</ArticleId></ArticleIdList></Reference><Reference><Citation>Food Chem Toxicol. 2010 Oct;48(10):2741-6</Citation><ArticleIdList><ArticleId IdType="pubmed">20637254</ArticleId></ArticleIdList></Reference><Reference><Citation>Fitoterapia. 2010 Oct;81(7):855-8</Citation><ArticleIdList><ArticleId IdType="pubmed">20546845</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1999 Jun 10;399(6736):601-5</Citation><ArticleIdList><ArticleId IdType="pubmed">10376603</ArticleId></ArticleIdList></Reference><Reference><Citation>Phytother Res. 2003 May;17(5):485-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12748984</ArticleId></ArticleIdList></Reference><Reference><Citation>Rejuvenation Res. 2010 Oct;13(5):589-98</Citation><ArticleIdList><ArticleId IdType="pubmed">21142669</ArticleId></ArticleIdList></Reference><Reference><Citation>Biol Trace Elem Res. 2011 Jun;141(1-3):246-53</Citation><ArticleIdList><ArticleId IdType="pubmed">20563666</ArticleId></ArticleIdList></Reference><Reference><Citation>Arzneimittelforschung. 2010;60(6):330-5</Citation><ArticleIdList><ArticleId IdType="pubmed">20648923</ArticleId></ArticleIdList></Reference><Reference><Citation>J Agric Food Chem. 2011 May 11;59(9):4527-36</Citation><ArticleIdList><ArticleId IdType="pubmed">21425781</ArticleId></ArticleIdList></Reference><Reference><Citation>Chin Med J (Engl). 2008 May 5;121(9):832-9</Citation><ArticleIdList><ArticleId IdType="pubmed">18701050</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Pharmacol. 2004 Oct 1;500(1-3):299-313</Citation><ArticleIdList><ArticleId IdType="pubmed">15464042</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods Enzymol. 1996;269:134-48</Citation><ArticleIdList><ArticleId IdType="pubmed">8791644</ArticleId></ArticleIdList></Reference><Reference><Citation>Cardiovasc Res. 2007 Jan 15;73(2):404-13</Citation><ArticleIdList><ArticleId IdType="pubmed">16962569</ArticleId></ArticleIdList></Reference><Reference><Citation>Arzneimittelforschung. 1996 Aug;46(8):809-14</Citation><ArticleIdList><ArticleId IdType="pubmed">9125284</ArticleId></ArticleIdList></Reference><Reference><Citation>Physiol Rev. 2010 Jan;90(1):113-78</Citation><ArticleIdList><ArticleId IdType="pubmed">20086075</ArticleId></ArticleIdList></Reference><Reference><Citation>J Nutr Biochem. 2004 Jul;15(7):426-32</Citation><ArticleIdList><ArticleId IdType="pubmed">15219928</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Pharmacol. 2003 Nov 28;481(2-3):227-32</Citation><ArticleIdList><ArticleId IdType="pubmed">14642790</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Hypertens. 2011;2011:281240</Citation><ArticleIdList><ArticleId IdType="pubmed">21915370</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioresour Technol. 2005 May;96(8):873-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15627557</ArticleId></ArticleIdList></Reference><Reference><Citation>Asian Pac J Trop Med. 2011 Dec;4(12):952-8</Citation><ArticleIdList><ArticleId IdType="pubmed">22118030</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Biol Toxicol. 2013 Apr;29(2):75-84</Citation><ArticleIdList><ArticleId IdType="pubmed">23463459</ArticleId></ArticleIdList></Reference><Reference><Citation>Evid Based Complement Alternat Med. 2005 Mar;2(1):29-32</Citation><ArticleIdList><ArticleId IdType="pubmed">15841275</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Algérie</li></country></list><tree><noCountry><name sortKey="Atmani Kilani, Dina" sort="Atmani Kilani, Dina" uniqKey="Atmani Kilani D" first="Dina" last="Atmani-Kilani">Dina Atmani-Kilani</name><name sortKey="Atmani, Djebbar" sort="Atmani, Djebbar" uniqKey="Atmani D" first="Djebbar" last="Atmani">Djebbar Atmani</name><name sortKey="Djebbli, Nouredine" 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